Any unused propofol remaining at the end of 28 days should be discarded. The opened vial should be placed in a covered container, held at room temperature and used within the allotted 28 day timeframe.

To avoid microbial overgrowth, the contents must be used within 28 days (4 weeks) of the date opened. The opened vial should be labeled with “Date Opened” and “Use By” in the space provided. Once a vial is opened, the contents begin a 28-day shelf life. Do not use if contamination is suspected. Failure to follow aseptic handling procedures may result in microbial contamination causing fever, infection/sepsis, and/or other life threatening illness. Strict aseptic techniques must always be maintained during handling. Do not use if particulate matter and discoloration are present. Slight creaming, which should disappear after shaking, may be visible upon prolonged standing. Do not use if there is evidence of excessive creaming or aggregation, if large droplets are visible, or if there are other forms of phase separation indicating that the stability of the product has been compromised. Propofol is a white stable emulsion do not use if there is evidence of separation of the phases. Shake the vial thoroughly before opening. Administer by intravenous injection only.

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